Diagnosis

On This Page:

• How Is Pancreatic Cancer Diagnosed?
• Pancreatic Cancer Tests
• Questions to Ask Your Doctor
• What to Do After Diagnosis
• Early Detection

How Is Pancreatic Cancer Diagnosed?

If you have pancreatic cancer symptoms, your doctor must do a few things to see if you have pancreatic cancer. The doctor will:

• Ask about your medical and family history
• Perform a physical exam, looking at your body, skin and eyes and pressing on your abdomen to check for changes around the pancreas, liver and gallbladder
• Possibly order blood, urine and stool tests
• Order an imaging study, like a computed tomography (CT) scan or magnetic resonance imaging (MRI)
• Get a tissue sample, called a biopsy

Pancreatic Cancer Tests

To be sure of a pancreatic cancer diagnosis, your doctors must get information from imaging tests and tumor tissue samples. Blood tests can also give them good information.

Imaging Tests

Imaging studies give doctors visual information about the pancreas and surrounding tissues. They are the only way to see a pancreatic tumor. So, imaging tests are critical in diagnosing and monitoring pancreatic cancer.

Doctors often use a computed tomography (CT) scan to see if the cancer has spread to nearby organs. A CT scan takes detailed pictures of the body.

Other imaging tests include:

• Magnetic Resonance Imaging (MRI): Uses radio waves and magnets to take pictures of organs and structures inside the body by measuring their energy
• Positron Emission Tomography (PET) Scan: Makes images based on the level of chemical reactions happening in cells
• Endoscopic Retrograde Cholangiopancreatography (ERCP): Takes x-ray pictures after a dye is injected through a thin tube
• Endoscopic Ultrasound (EUS): A thin tube, called an endoscope, with an ultrasound probe is passed through the patient’s mouth and into the stomach or duodenum to take pictures of the pancreas, bile duct and digestive tract
• Laparoscopy: A surgeon inserts a camera through a small cut in the abdomen to look at the organs

Blood Tests and Tumor Markers for Pancreatic Exocrine Tumors

There is no blood test or tumor marker to find or diagnose pancreatic exocrine tumors, the most common type of pancreatic tumor.

A pancreatic tumor blocking the bile duct can cause higher bilirubin and liver enzyme levels in the blood. High levels of these substances in blood can be a clue for doctors to look for pancreatic cancer. But this does not happen in all pancreatic cancer patients.

After diagnosis, two blood tests may help your doctor see if your tumor is growing, staying the same or responding well to treatment. These tests measure substances some pancreatic cancer cells release into your blood, including:

• Carbohydrate antigen 19-9 (CA 19-9)
• Carcinoembryonic antigen (CEA)

Not all pancreatic tumors release these substances, and other cancer types and illnesses can also release them. So, they cannot be used to diagnose pancreatic cancer.

Blood Tests and Tumor Markers for Pancreatic Neuroendocrine Tumors

There is not one specific blood test that can find or diagnose pancreatic neuroendocrine tumors (PNETs). But some blood tests can help with diagnosis.

These tests measure:

• Chromogranin A (cgA): A molecule that is high in most people with PNETs
• Pancreatic polypeptide (PP): A hormone often high in people with PNETs
• Specific hormones made by pancreatic neuroendocrine tumors

Doctors can use these blood tests along with imaging tests to get more information to diagnose a pancreatic neuroendocrine tumor.

Biopsy

The only way for your doctor to know if a mass or tumor is cancer is to get a tissue sample, called a biopsy.

Your doctor can get a biopsy through surgery or procedures like endoscopic ultrasound (EUS) or endoscopic cholangiopancreatography (ERCP).

Then, a pathologist looks at the tissue samples under a microscope. The shape, size and arrangement of the cancer cells may help your doctors figure out the type of pancreatic cancer.

Learn more about pancreatic cancer biopsies.

Molecular Profiling

After getting a tumor tissue sample, your doctor may run tests to understand your tumor’s biological details. This is called molecular profiling. Your doctor may be able to use this information to make treatment decisions.

Every pancreatic tumor is different. Patients who receive treatment based on their tumor’s biological characteristics have better outcomes. The Pancreatic Cancer Action Network strongly recommends molecular profiling of your tumor to help determine the best treatment options.

Screening Tests

No universal screening tests for pancreatic cancer exist yet. But researchers across the country are studying people who have a high chance of getting pancreatic cancer.

The Pancreatic Cancer Action Network strongly recommends consulting with a genetic counselor to determine your risk and eligibility for a screening program if you have:

• Two or more first-degree relatives who have had pancreatic cancer
• A first-degree relative who developed pancreatic cancer before the age of 50
• An inherited genetic syndrome associated with pancreatic cancer

Contact Patient Central for more information about screening, risk factors or genetic counseling.

Questions to Ask Your Doctor

When talking to your doctor about your diagnosis, some helpful questions to ask are:

• What tests and scans will you use to confirm a pancreatic cancer diagnosis?
• How many people with pancreatic cancer do you diagnose each year?
• If I would like a second opinion, can you recommend another gastroenterologist?
• What is my specific diagnosis? What type of pancreatic cancer do I have?
• Where did the cancer start? Is the cancer in the head, body or tail of my pancreas?
• Has my cancer spread? Do I need more tests to check if it has spread?
• What is the stage of the cancer? What does that mean?

Some questions to ask your doctor to help you figure out next steps are:

• Can my tumor be removed through surgery? Why or why not?
• What treatment choices do I have?
• Should my family and I be tested for hereditary pancreatic cancer?
• What kind of doctor should I see for treatment(s)?
• Can you recommend doctors to me? Why do you recommend these doctors?
• Will you be involved in any of my treatment or follow-up?
• Will you or someone else help treat symptoms and side effects?
• Can you recommend support resources?

What to Do After Diagnosis

A pancreatic cancer diagnosis can be overwhelming, and you may not know what to do next. Being informed helps you make the best decisions for you.

After diagnosis:

• Learn the basics about pancreatic cancer and your particular diagnosis
• Get copies of your records
• Get a second opinion
• Choose your healthcare team
• Learn about treatment options
• Get resources and support

Patient Central can give you resources and information to help with any of these steps. This includes lists of specialists in your area, treatment information and personalized clinical trials searches. They can also answer any questions you have about the disease.

Understand What Your Diagnosis Means

Knowing details about your diagnosis helps you make decisions. Important things to know include:

• The type of pancreatic cancer
• Your cancer’s stage
• Where the tumors are located
• If the cancer has spread
• If surgery is possible
• Treatment options for your diagnosis

Get a Second Opinion from a Specialist

You have a right to get a second opinion. Pancreatic cancer is rare, and general oncologists are not always familiar with treating it. The Pancreatic Cancer Action Network strongly recommends you seek a second opinion, as needed, at any point in your diagnosis.

It is important to get a second opinion from a doctor who has experience treating people with pancreatic cancer. Learn more about what to think about when choosing your healthcare team.

Know All Your Treatment Options

You are your own best advocate. The Pancreatic Cancer Action Network strongly recommends that you discuss your treatment goals with your healthcare team and know all of your options at every stage of your disease.

Standard treatments for pancreatic cancer are surgery, chemotherapy, radiation or a mix of these. But it is also important to consider clinical trials and treatments based on your tumor’s biology, called precision medicine.

Contact Patient Central for more free information about treatment options, a personalized clinical trials search or information about our precision medicine service.

Early Detection

Today, there is no established way or test to find pancreatic cancer early. Reasons for this include:

• The pancreas is located deep in the abdomen, so doctors usually cannot see or feel the tumor during a physical exam
• Pancreatic cancer symptoms are not always obvious and usually develop over time
• There are no proven molecular clues, called biomarkers, that can help doctors tell that you have the disease early

But researchers are working hard to figure out ways to find pancreatic cancer early. Learn more about pancreatic cancer early detection.

We’re Here to Help

For free, in-depth and personalized resources and information on pancreatic cancer diagnosis and treatment, contact Patient Central.

Related Topics

Information reviewed by PanCAN’s Scientific and Medical Advisory Board, who are experts in the field from such institutions as University of Pennsylvania, Memorial Sloan-Kettering Cancer Center, Virginia Mason Medical Center and more.

Information provided by the Pancreatic Cancer Action Network, Inc. (“PanCAN”) is not a substitute for medical advice, diagnosis, treatment or other health care services. PanCAN may provide information to you about physicians, products, services, clinical trials or treatments related to pancreatic cancer, but PanCAN does not recommend nor endorse any particular health care resource. In addition, please note any personal information you provide to PanCAN’s staff during telephone and/or email communications may be stored and used to help PanCAN achieve its mission of assisting patients with, and finding cures and treatments for, pancreatic cancer. Stored constituent information may be used to inform PanCAN programs and activities. Information also may be provided in aggregate or limited formats to third parties to guide future pancreatic cancer research and education efforts. PanCAN will not provide personal directly identifying information (such as your name or contact information) to such third parties without your prior written consent unless required or permitted by law to do so. For more information on how we may use your information, you can find our privacy policy on our website at https://www.pancan.org/privacy/.