Treatment

Grants classified within this field of interest focus on treatment of pancreatic cancer. According to the Common Scientific Outline, these projects deal with one or more of the following research topics: (1) localized therapies – discovery and development; (2) localized therapies – clinical applications; (3) systemic therapies – discovery and development; (4) systemic therapies – clinical applications; (5) combinations of localized and systemic therapies; (6) complementary and alternative treatment approaches; and (7) resources and infrastructure related to treatment. Click below to learn about these grants.

2013 Samuel Stroum – Pancreatic Cancer Action Network – AACR Fellowship
Andrew Aguirre, MD, PhD
Dana-Farber Cancer Institute
Validation of Novel KRAS Synthetic Lethal Targets in Pancreatic Cancer

2008 Randy Pausch, PhD – Pancreatic Cancer Action Network – AACR Pilot Grant
Nabeel Bardeesy, PhD
Massachusetts General Hospital
Molecular Markers of Drug Sensitivity in Pancreatic Cancer

2010 Samuel Stroum – Pancreatic Cancer Action Network – AACR Fellowship Award
Vikram Bhattacharjee, PhD
Fox Chase Cancer Center
Candidate Gene Validation of Sensitizers of Pancreatic Cancer to Gemcitabine

2014 Pancreatic Cancer Action Network – Rising Tide Foundation – Gateway Clinical Continuation Research Grant
David Boothman, PhD
University of Texas Southwestern Medical Center
Exploiting an NQO1 ‘kiss of death’ for pancreatic cancer therapy

2013 Abby Sobrato – Pancreatic Cancer Action Network – AACR Innovative Grant
Yves Boucher, PhD
Harvard Medical School
Targeting Desmoplasia in Pancreatic Cancer to Improve Drug Efficacy

Seena Magowitz – Pancreatic Cancer Action Network -- AACR Pilot Grant
George A. Calin, MD, PhD
MD Anderson Cancer Center
Roles of MicroRNAs and Ultraconserved Genes in Pancreatic Cancers

2012 The Daniel and Janet Mordecai Foundation – Pancreatic Cancer Action Network – AACR Career Development Award
Darren Carpizo, MD, PhD
University of Medicine & Dentistry of New Jersey – Robert Wood Johnson Medical School
Pre-clinical Studies of an Allele-Specific p53 Mutant Reactivating Compound in Pancreatic Cancer

2006 Pancreatic Cancer Action Network – ASCO Career Development Award
David Chang, MD, PhD
MD Anderson Cancer Center
Treating Pancreatic Cancer with the Well-characterized Anti-allergy Drug Cromolyn, Through a Novel Mechanism of Action

2008 Constance Williams – Pancreatic Cancer Action Network – AACR Career Development Award
Marie-Christine Daniel, PhD
University of Maryland, Baltimore County
Multifunctional Nanovectors for Pancreatic Cancer Therapy

2014 Skip Viragh – Pancreatic Cancer Action Network – AACR Research Acceleration Network Grant
Giulio Draetta, MD, PhD, MD Anderson Cancer Center
Co-Principal Investigator: Lewis Cantley, PhD, Weill Cornell Medical College
Developing a Novel Oxidative Phosphorylation Inhibitor in Pancreatic Cancer

2012 Bonnie L. Tobin – Pancreatic Cancer Action Network – AACR Innovative Grant
Peter Espenshade, PhD
Johns Hopkins University
SREBP Pathway as a Target for Pancreatic Cancer Therapy

2014 Samuel Stroum – Pancreatic Cancer Action Network – AACR Fellowship
Barbara Grüner, PhD
Stanford University
Multiplexed In Vivo Drug Screening: Inhibitors of Metastatic Seeding

2007 Pancreatic Cancer Action Network Pilot Grant
Douglas Hanahan, PhD
University of California, San Francisco
Assessing Mechanisms and Therapeutic Potential of an Aspartyle Protease in Pancreatic Cancer

2005 Skip Viragh – Pancreatic Cancer Action Network – AACR Career Development Award
William G. Hawkins, MD
Washington University in St. Louis
Assessing the Ability of Regulatory T-Cell Depletion to Augment Xenogeneic DNA Vaccination Against Mesothelin as a Method to Overcome Immunologic Tolerance in a Murine Model of Pancreas Cancer

2008 Blum-Kovler – Pancreatic Cancer Action Network – AACR Career Development Award
Joseph Michael Herman, MD
Johns Hopkins University
Evaluation of Focused Radiation to Potentiate a Pancreatic GM-CSF Vaccine

2005 Samuel Stroum – Pancreatic Cancer Action Network – ASCO Young Investigator Award
Aram Hezel, MD
Dana-Farber Cancer Institute
Novel Therapeutic Antibodies for Pancreatic Ductal Adenocarcinoma

2007 Pancreatic Cancer Action Network Pilot Grant
Sunil R. Hingorani, MD, PhD
Fred Hutchinson Cancer Research Center
Activated Kras G12D and Oncogene Dependence in Pancreatic Cancer

2004 Samuel Stroum – Pancreatic Cancer Action Network – ASCO Young Investigator Award
David S. Hong, MD
MD Anderson Cancer Center
SRC Kinase Inhibition with BMS-354825 in Pancreatic Cancer Models

2007 Samuel Stroum – Pancreatic Cancer Action Network -- AACR Young Investigator Award
Hiroyuki Kashiwagi, MD
Washington University in St. Louis
Targeted Delivery of Pro-Apoptotic Therapeutics in Pancreatic Cancer

2014 Fredman Family Foundation – Pancreatic Cancer Action Network – AACR Research Acceleration Network Grant
Dung Le, MD, Johns Hopkins University
Co-Principal Investigator: Todd Crocenzi, MD, Providence Portland Medical Center
GVAX + CRS-207 Heterologous Prime Boost Vaccination with PD-1 Blockade

2008 Pancreatic Cancer Action Network – AACR Pilot Grant
Bin Liu, PhD
University of California, San Francisco
Internalizing Human Antibodies Targeting Pancreatic Tumor Cells In Situ

2013 Pancreatic Cancer Action Network – AACR Career Development Award
Eric Lutz, PhD
Johns Hopkins University
Exploiting the cancer mutome for personalized tumor immunotherapy

2004 Pancreatic Cancer Action Network – AACR Career Development Award
Anirban Maitra, MD
Johns Hopkins University
Notch Signaling in Pancreas Cancer

2010 Pancreatic Cancer Action Network – AACR Innovative Grant
Frank McCormick, PhD
University of California, San Francisco
Specific K-Ras Inhibitors for Treating Pancreatic Cancer

2007 Pancreatic Cancer Action Network Pilot Grant
Pinku Mukherjee, PhD
Mayo Clinic, Scottsdale
Development of Immune-Modulating Therapies Delivered Directly to the Pancreatic Tumor Site

2003 Pancreatic Cancer Action Netwrk – AACR Career Development Award
C. Max Schmidt, MD, PhD
Indiana University
The Chemopreventive Role of Cyclooxygenase Inhibitors in Pancreatic Tumorigenesis

2010 The Randy Pausch Family – Pancreatic Cancer Action Network – AACR Innovative Grant
Diane Simeone, MD
University of Michigan, Ann Arbor
Targeting Notch Signaling in Pancreatic Cancer Stem Cells

2008 Patty Boshell – Pancreatic Cancer Action Network – AACR Career Development Award
Peter Storz, PhD
Mayo Clinic, Jacksonville
Kinases Regulating Pancreatic Cancer Resistance to Chemotherapeutics

2010 Pancreatic Cancer Action Network – AACR Innovative Grant
Gloria Su, PhD
Columbia University
Notch Decoy Signaling in Pancreatic Cancer Stem Cells

2012 The Daniel and Janet Mordecai Foundation – Pancreatic Cancer Action Network – AACR Career Development Award
Kazuki Sugahara, MD, PhD
Sanford-Burnham Medical Research Institute
Tissue-Penetrating Drug Delivery to Desmoplastic Pancreatic Tumors

2007 Seena Magowitz – Pancreatic Cancer Action Network – AACR Career Development Award
Rebekah White, MD
Duke University Medical Center
Prostate Stem Cell Antigen: A Specific Target for Pancreatic Cancer Therapy

2013 Tempur-Pedic – Pancreatic Cancer Action Network – AACR Inaugural Research Acceleration Network Grant in Memory of Tim Miller
Robert Vonderheide, MD, DPhil, University of Pennsylvania
Co-PI: Dafna Bar-Sagi, PhD, New York University
Accelerating Development of CD40 Therapy for Pancreatic Cancer